Antiplatelet drugs effect may be increased or decreased. A powerpoint presentation on antiplatelet drugs suitable for ug mbbs level. Learning objectives by the end of this lecture, students should be able to. Antiplatelet drugs are medicines used to prevent thrombus formation. Call your healthcare provider right away or go to the closest emergency room if you have. Normally when endothelial injury occurs, it exposes tissues to platelets, leading to activation and aggregation.
An increase in antiplatelet effect would increase the risk of bleeding and results in prolonged or excessive bleeding. Apr 21, 20 anticoagulants are the cornerstone therapy for thrombosis prevention and treatment. Antiplatelet drugs are therefore important for the prevention and treatment of intracardiac and arterial thrombosis and their consequences. Department of pharmacology university of michigan medical school mode of action of antiplatelet agents ticlopidine ticlid platelet inhibition is irreversible. Anticoagulation drugs represent a rapidly expanding field, with many novel agents in various stages of testing and approval.
As such, they are used in the treatment and prevention of heart attacks, stroke, and other cardiovascular illnesses. Supplement antithrombotic and thrombolytic therapy 8th ed. Antiplatelet drugs are intended to prevent andor reverse platelet aggregation in arterial thrombosis, most prominently in myocardial infarction and ischaemic stroke. Ppt pharmacology of antiplatelet agents powerpoint. The focus of this chapter is on elements of anticoagulant clinical pharmacology that are important for anesthesiologists to understand. They are effective in the arterial circulation, where anticoagulants have little effect. Pharmacology 6th edition pdf using our mediafire repository links. Therapeutics within each category differs with respect to the mechanism of action, time to onset, duration of effect and route of administration. Antiplatelet drugs are a group of powerful medicines that prevent blood clots when you are wounded, platelets arrive on the scene and group together to form a clot that stops the bleeding. Ticagrelor, elinogrel, cangrelor, bx 667 gpiib iiia antagonist. The currently available antiplatelet drugs target key steps of platelet activation including thromboxane a 2 synthesis, adpmediated. Aspirin acetylsalicylic acid is the most prescribed antiplatelet drug for prevention of cardiovascular disorders. Blood must remain fluid within the vasculature and yet clot quickly when exposed to subendothelial surfaces at sites of vascular injury. Anticoagulants remain the primary strategy for the prevention and treatment of thrombosis.
Ppt antiplatelet and thrombolytic drugs powerpoint. Worlds best powerpoint templates crystalgraphics offers more powerpoint templates than anyone else in the world, with over 4 million to choose from. Ppt pharmacology of antiplatelet agents powerpoint presentation free to view id. Jul 05, 2016 brahma associate professor department of pharmacology neigrihms, shillong antiplatelet drugs antithrombotic drugs 2. Antithrombotic drugs, which include antiplatelet and anticoagulant therapies, prevent and treat many cardiovascular disorders and, as such, are some of the most commonly prescribed drugs worldwide. Antiplatelet, anticoagulant and thrombolytic drugs at. Antiplatelet drugs like aspirin dipyridamole abciximab clopidogrel ticlopidine prasugrel. Antiplatelet drug is a generic term, describing agents which decrease platelet aggregation and inhibit thrombus formation. A report of the american college of cardiologyamerican heart association task force on clinical practice guidelines. The dynamics of drug absorption, distribution, action and elimination. View pharmacology ppts online, safely and virusfree. The relationships among dose, efficacy, and safety are discussed along with a mechanistic overview of results of randomized clinical trials. Patients who require the use of antiplatelet drugs could have suffered a stroke or have a heart surgery. Adp antagonists thienopyridines, cox1 inhibitors the only member of this class is aspirin.
Drugs for acute coronary syndromes cardiovascular disorders. In older patients presenting to an emergency department with a warfarin adverse drug event, about half required hospitalization. If you get a cut or nosebleed, gently press on it until the bleeding stops. Remove this presentation flag as inappropriate i dont like this i like this remember as a favorite. Antiplatelet drugs an overview sciencedirect topics. The 3 main drugs used in those trials, that is, aspirin. Role of clinical pharmacology in the development of. Classification of antiplatelet drugs drug group sub groups route name of drugs 1 irreversible cox inhibitor oral aspirin low dose 2 adp receptor blockers p2y thienopyridines oral clopidogrel, prasugrel, ticlopidine, ticagrelor 3 glycoprotein iibiiia inhibitors monoclonal antibody iv abciximab peptide inhibitors iv eptifibatide, tirofiban 4. View test prep antiplatelet drugs from phil phil 1600 at university of colorado, boulder. These drugs are used to reduce the risk of heart attacks and.
An update of the 2011 accfahascai guideline for percutaneous coronary intervention, 2011 accfaha guideline for. The figure below shows how antiplatelet drugs can be classified according to their mechanism of action. Nov 29, 2016 acute coronary syndrome acs is a term used to encompass unstable angina ua and myocardial infarction mi with or without electrocardiographic ecg evidence of stsegment elevation. Test your knowledge of this class with our antiplatelet drugs quiz ten questions covering just about everything you need to know. Anticoagulant, thrombolytic, and antiplatelet drugs katzung 9th ed. Plateletaggregation inhibition is not significant until after approximately 4 days of regular dosing. Antiplatelet drugs affect the fluidity of blood in thromboembolic conditions.
We have tested this download and found it clean and absolutely genuine. Anticoagulants, antiplatelet drugs and thrombolytic agents. Atherothrombosis research centre laboratory of biochemistry, department of chemistry, university of ioannina, 45110 ioannina, laboratory of biochemistry, department of. Antiplatelet drugs effect may be affected by patients medications, current medical conditions, food and supplements taken. Learn pharm test 3 pharmacology drugs antiplatelet with free interactive flashcards. Lifeblood the thrombosis charity antiplatelet and thrombolytic drugs these slides were kindly provided by astrazeneca.
Anticoagulant, thrombolytic, and anti platelet drugs katzung 9th ed. Platelets aggregate as haemostatic plugs at the site of vascular injury, whereby bleeding is limited or arrested in advance of plasma coagulation figure 1. The first randomized controlled trials rcts of antiplatelet therapy were reported 40 years ago. Antiplatelet medications heart and stroke foundation. Pharmacodynamic properties of antiplatelet agents medscape. Antiplatelet drugs, such as aspirin, prevent blood cells called platelets from clumping together to form a clot. During this activation, different substances are synthesized and released, leading to. Antiplatelet agents play a major role in the treatment and prevention of myocardial infarction heart attacks, stent thrombosis, and ischemic stroke strokes caused by a blood clot. An antiplatelet drug antiaggregant, also known as a platelet agglutination inhibitor or platelet aggregation inhibitor, is a member of a class of pharmaceuticals that decrease platelet aggregation and inhibit thrombus formation. Clopidogrel plavix is an inexpensive drug used to prevent heart attack, stroke, or other events in people who are at high risk.
While anticoagulants are commonly employed, their use is often associated with adverse drug events and increased readmission rates. Definition drugs which interfere with platelet function and are useful in prophylaxis of thromboembolic disorders the principal function of platelets is to prevent bleeding by thrombus formation 3. The unique quiz below tests out how much you know about these types of medication. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Under normal circumstances, a delicate balance between coagulation and fibrinolysis prevents both thrombosis and hemorrhage. The article describes the mechanisms of action, pharmacokinetics, and pharmacodynamics of aspirin, dipyridamole, cilostazol, the thienopyridines, and the glycoprotein iibiiia antagonists. Set 1 powerpoint links collected from the website of. Choose from 500 different sets of pharm test 3 pharmacology drugs antiplatelet flashcards on quizlet. Nov 25, 20 antiplatelet drugs are therefore important for the prevention and treatment of intracardiac and arterial thrombosis and their consequences. Theyll give your presentations a professional, memorable appearance the kind of sophisticated look that todays audiences expect. Definition drugs which interfere with platelet function and are useful in prophylaxis of thromboembolic disorders the principal function of platelets is to prevent.
Bleeding is the most important side effect of antiplatelet medications. Classification of antiplatelet drugs drug group sub groups route name of drugs 1 irreversible cox inhibitor oral. Jan 09, 2006 antiplatelet drugs are intended to prevent andor reverse platelet aggregation in arterial thrombosis, most prominently in myocardial infarction and ischaemic stroke. Definition of medication, antiplatelet medicinenet. Goodman and gilman pharmacology pdf download medicforyou. The therapeutic index is relevant to clinical practice because it determines how safe or toxic a drug is.
Pharmacology hematologic drugs coagulation bleeding. Critical facts if med school is a minnesota forest with millions of trees, these are the red pines 1. Winner of the standing ovation award for best powerpoint templates from presentations magazine. Unfractionated heparin, low molecular weight heparin, fondaparinux, and warfarin have been studied and employed extensively with direct thrombin inhibitors typically reserved for patients with complications or those requiring intervention. The goodrx fair price represents the maximum price that a consumer, with or without insurance, should pay for this drug at a local pharmacy. Scribd is the worlds largest social reading and publishing site. These agents modulate hemostasis by affecting clotting mechanisms in platelets, clotting factors, or for. Antiplatelet drugs antithrombotics linkedin slideshare. Blood coagulation and anticoagulant, fibrinolytic, and. The goodman and gilman has 15 sections covering 65 chapters and appendices which are listed as below. Pharmacology hematologic drugs free download as powerpoint presentation.
Platelets play an important role in atherothrombotic disease. Chapter 34 this version has been changed compared to the one made available on wednesday april 26 sorry. This short tutorial explains how this ratio is calculated. Blood when you throw up, or vomit that looks like coffee grounds. Reports of late coronary and carotid artery stent occlusion, particularly in the perioperative period after discontinuation of an antiplatelet drug,34 have served to. Ajw200, arc1779, arc15105, alx0081, 82d6 a3 gpvi receptor antagonists. Definition drugs which interfere with platelet function and are useful in prophylaxis of thromboembolic disorders the principal function of platelets is to prevent bleeding by thrombus formation.
Theyll give your presentations a professional, memorable appearance the kind of sophisticated look that. Mar 05, 2018 antiplatelet drugs like aspirin dipyridamole abciximab clopidogrel ticlopidine prasugrel. Anticoagulant, thrombolytic, and antiplatelet drugs. The pharmacological basis of therapeutics, e brunton ll, hilaldandan r, knollmann bc. Newer antiplatelet drugs authorstream presentation. Anticoagulants, thrombolytics agents and antiplatelet drugs author. Brahma associate professor department of pharmacology neigrihms, shillong antiplatelet drugs antithrombotic drugs 2. Pharmacology of antiplatelet agents is the property of its rightful owner. Antiplatelet and anticoagulant pharmacology for the. Platelets are critical in haemostasis and the development of arterial thrombi. Popularity is based on total prescriptions for the brand and generic versions of each drug. Antiplatelet drugs are most effective for arterial clots that are composed largely of platelets. Anticoagulants, thrombolytics agents and antiplatelet drugs.
Pdf antiplatelet and anticoagulant drugs in interventional. Antiplatelet therapy has formed the backbone of acs management for decades and the drug class continues to evolve as novel agents with increasingly efficacious. Antiplatelet drugs free download as powerpoint presentation. An update of the 2011 accfahascai guideline for percutaneous coronary intervention, 2011 accfaha. Antiplatelet agents inhibit clot formation by preventing platelet activation and aggregation, while anticoagulants primarily inhibit the coagulation cascade and fibrin formation.
Anticoagulants, commonly referred to as blood thinners, are drugs that prevent or reduce coagulation of blood, prolonging the clotting time. The article does not provide specific management recommendations. Contents introduction classification individual drugs newer antiplatelet. Syed shariq naeem, senior resident doctor, department of clinical pharmacology, maulana azad medical college, new delhi india download to play animations classification of antiplatelet drugs. A related article explores the pharmacology of thrombolytic agents.
Generic clopidogrel is covered by most medicare and insurance plans, but manufacturer and pharmacy coupons can help offset the cost. Acute coronary syndrome acs is a term used to encompass unstable angina ua and myocardial infarction mi with or without electrocardiographic ecg evidence of stsegment elevation. Drugs that reduce the tendency of platelets in the blood to clump and clot. Antiplatelet drugs and anticoagulant medicines are the mainstay of drug treatments for prevention of stroke, whereas fibrinolytics are the principal treatment for most individuals with acute ischemic stroke within the treatment time window. Antiplatelet agents are medicines that reduce the ability of platelets to stick together called platelet aggregation and inhibit the formation of blood clots. Syed shariq naeem, senior resident doctor, department of clinical pharmacology, maulana azad medical college, new delhi india download to play animations. These drugs are used to treat strokes, myocardial infarctions, pulmonary embolisms, disseminated intravascular coagulation dic and deep vein thrombosis. Pharmacology 6th edition pdf free download section. If so, share your ppt presentation slides online with. Weitz blood coagulation and anticoagulant, fibrinolytic, and antiplatelet drugs. The first drugs designed to inhibit platelets or coagulation factors, such as the antiplatelet clopidogrel and the anticoagulant warfarin, significantly reduced the risk of thrombotic events at the. Anticoagulants, antiplatelet drugs and thrombolytic agents presentation summary major classes of drugs platelet activation aspirin newer antiplatelets thienopyridines caprie trial cure trial match trial glycoprotein iibiiia antagonists fibrinogenesis heparin mechanism of action features of low molecular weight heparin lmwh vs unfractionated heparin warfarin.